Characterization of Heat Shock Protein (HSP 70) Sequence in Leishmania donovani
نویسندگان
چکیده
منابع مشابه
Leishmania donovani heat shock protein 100. Characterization and function in amastigote stage differentiation.
We report the cloning and molecular analysis of the Leishmania donovani clpB gene. The protein-coding region is highly conserved compared with its L. major homologue, while 5'- and 3'-flanking DNA sequences display considerable divergence. The encoded mRNA has an unusually long 5'-leader sequence typical for RNAs, which are translated preferentially under heat stress. The gene product, a 100-kD...
متن کاملSpecies-specific collaboration of heat shock proteins (Hsp) 70 and 100 in thermotolerance and protein disaggregation.
Yeast Hsp104 and its bacterial homolog, ClpB, are Clp/Hsp100 molecular chaperones and AAA+ ATPases. Hsp104 and ClpB collaborate with the Hsp70 and DnaK chaperone systems, respectively, to retrieve and reactivate stress-denatured proteins from aggregates. The action of Hsp104 and ClpB in promoting cell survival following heat stress is species-specific: Hsp104 cannot function in bacteria and Clp...
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amebiasis caused by entamoeba histolytica is still mentioned as one of the major health problems in tropical and subtropical areas. e. histolytica has recently been redescribed as two distinct species; e. histolytica and e. dispar. in the present study, we characterized the 70 kda heat shock protein (hsp70) of e. dispar at molecular level and compared it with that of e. histolytica. with these ...
متن کاملThe protection role of heat shock protein 70 (HSP-70) in the testes of cadmium-exposed rats
Cadmium (Cd) is an environmental carcinogenic pollutant known to inactivate several proteins involved in DNA repair systems while at the same time creating an oxidative stress that can result in additional DNA lesions. The testis and the lung are the target organs for cadmium carcinogenesis. Increased production of oxidants in vivo can cause damage to intracellular macromolecules such as DNA, p...
متن کاملEvaluation of Salivary Level of Heat Shock Protein 70 in Patients with Breast Cancer
Introduction: Breast cancer is the most common cancer diagnosed among women worldwide. Increased molecular and genetic information about cancer has improved diagnostic, screening, and treatment methods for cancer. Heat shock protein 70 (HSP70) is overexpressed in breast cancer patients and involved in malignant properties of breast cancer. Due to the noninvasive nature of saliva collection and ...
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ژورنال
عنوان ژورنال: Journal of Institute of Science and Technology
سال: 2015
ISSN: 2467-9240
DOI: 10.3126/jist.v20i1.13914